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Curtin University
Staff Profile

Associate Professor David Groth

Associate Professor David Groth Associate Professor David Groth

BSc(Hons)(W. Aust), MAppSc (Curtin), PhD (W. Aust)

Position Associate Professor
Faculty Faculty of Health Sciences
School School of Biomedical Sciences
Campus Bentley Campus
Location 305.121
Phone 08 9266 7475
Fax 08 9266 2342
Email D.Groth@curtin.edu.au

Memberships, Awards and Training

Chair of Scientific Advisory Committee McCusker Research Foundation for Alzheimer's Disease

Member of the Board of the McCusker Research Foundation for Alzheimer's Disease

Chair of the Institutional Biosafety Committee (Curtin University)

Member of the American Society for the Advancement of Science

Member of the International Forensic Genetic Society

Member of Genetic Society (UK)

Member of Genetic Society of America

Member of International Society of Animal Genetics

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Teaching

My main contributions to teaching and learning have been in the development and revision of new units in the rapidly developing and changing field of molecular genetics. These contributions have been critical in maintaining the scientific credibility of the School’s offering in contemporary molecular science.  Over the years I have participated in the University’s efforts to improve teaching and learning and make good use of electronic delivery and presentation of material and resources.  I enjoy excellent feedback from student evaluations of teaching and take considerable care in the delivery of the programs for which I am responsible.  I have actively mentored new staff members in many aspects of School/University functions.

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Research Interests

My research can be divided into four main areas;

(1) population genetics

Currently, I am supervising students involving in molecular genetics projects on the Noisy Scub Bird and the Western Swamp Tortoise.

The aims of this research are:

1. Development and use of molecular tools for the analysis of population genetics in these endangered species.

2. Use of next generation sequencing to discover microsatellites to assist in the above aim.

(2) Understanding the sheep major histocompatibility complex and other regions of the sheep genome and their role in sheep parasitic diseases.

The aims of this research are:

1. To develop a single nucleotide polymorphism map of the sheep MHC.

2. Apply SNPs to identifying genes involved with IgA and IgE responses to gastrointestinal parasites.

3. Use the information gained as a model for human IgE responses and systems involved in parasite responses.

4. Comparative analysis of the MHC

(3) The role of Corneodesmosin and other related desmosomal proteins in skin and hair/wool structure and their role in skin diseases and wool production traits

Aims of this research are:

1. Understand the effects of variation in corneodesmosin and other proteins found in the corneodesmosome on their structure and function.

2. Understand the possible role of Corneodesmosin and other related proteins in the pathogenesis of human skin diseases such as psoriasis.

(4) The molecular mechanisms of Alzheimer’s disease.  This work is in collaboration with Professor Ralph Martins from ECU. The research involves the construction of recombinant Baculoviral constructs and their use in determining the minimal gamma secretase complex required for amyloid-beta production.  

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Publications

2017

Journal Articles (Research)

2016

Journal Articles (Research)

2015

Journal Articles (Research)

2014

Journal Articles (Research)

2013

Journal Articles (Research)

2012

Journal Articles (Research)

2011

Journal Articles (Research)

2010

Journal Articles (Research)

2009

Journal Articles (Research)

Conference Articles (Research)

2008

Journal Articles (Research)

2005

Journal Articles (Research)

2004

Journal Articles (Research)

2003

Journal Articles (Research)

2002

Journal Articles (Research)

2000

Journal Articles (Research)

1997

Journal Articles (Research)

Conference Articles (Research)

1995

Journal Articles (Research)

1994

Journal Articles (Research)

1992

Journal Articles (Research)

1990

Journal Articles (Research)

1988

Journal Articles (Research)

1987

Journal Articles (Research)

1985

Journal Articles (Research)

Additional publication categories

2017

Journal Articles (Scholarly/Professional)

  • Margery-Muir, A., C. Bundell, D. J. Nelson, D. M. Groth, and J. Wetherall. 2017.“Gender balance in patients with systemic lupus erythematosus.”Autoimmunity Reviews 16 (3): 258-268.
  • Nelson, D. J., B. Clark, K. Munyard, V. Williams, D. M. Groth, J. Gill, H. Preston, and A. Chan. 2017.“A review of the importance of immune responses in luminal B breast cancer.”OncoImmunology 6 (3).

2013

Journal Articles (Scholarly/Professional)

2012

Journal Articles (Scholarly/Professional)

2009

Book Chapters - Other

Patents

  • Groth, D. M., K. Gregg, and K. A. Munyard. 2009. Detection of DNA Sequence Motifs in Ruminants NZ patent 560808. USA: World Intellectual Property Organization

2002

Journal Articles (Scholarly/Professional)

  • Hedley, R., J. Hallmayer, D. M. Groth, W. S. Brooks, S. E. Gandy, and R. N. Martins. 2002.“Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia.”Annals of Neurology 51 (6): 795-797.
  • Hedley, R., R. Martins, D. M. Groth, J. Hallmayer, and L. Schmitt. 2002.“Association of Interleukin-1 gene polymorphisms and Alzheimer's disease.”HOMO-JOURNAL OF COMPARATIVE HUMAN BIOLOGY 53 (2): 183-183.

1999

Journal Articles (Scholarly/Professional)

  • Taylor, E., P. Vercoe, J. Cockrem, D. M. Groth, J. Wetherall, and G. Martin. 1999.“Isolation and characterization of microsatellite loci in the emu, Dromaius novaehollandiae, and cross-species amplification within Ratitae.”Molecular Ecology 8 (11): 1963-1964.
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